--- title: "Abaloparatide Peptide UK - Compare Prices from 2 Suppliers - PeptideSupermarket®" description: "Compare Abaloparatide prices from 2 UK suppliers, from £79.00. Find the cheapest deals, read reviews and save money." url: "https://peptidesupermarket.co.uk/peptide/abaloparatide" site: "PeptideSupermarket®" country: "United Kingdom" --- [Home](https://peptidesupermarket.co.uk) › [Peptides](https://peptidesupermarket.co.uk/compare-peptide-prices-uk) › Abaloparatide Search # Abaloparatide Price Comparison Live prices from 2 UK suppliers, from £79.00, compared side by side so you never overpay. [Endocrine & reproductive](https://peptidesupermarket.co.uk/compare-peptide-prices-uk) Prices checked 2 hours ago We compare prices & may earn a commission. [Full disclosure](https://peptidesupermarket.co.uk/disclosure). Best Price £79.00 Average £82.00 Highest £85.00 You Could Save 7% 2 results 3mg Compare 2 prices for Abaloparatide. Cheapest: £79.00. Average: £82.00. | Compare | Supplier | Price | Price / mg | Stock | Delivery | Quality | Coupon | Visit | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | | 80 Confidence [Raccoon Peptides](https://peptidesupermarket.co.uk/suppliers/raccoon-peptides) Best ★★★★★ 5.0 (1) Abaloparatide | £79.00 | £26.33/mg | In Stock | Free | Lab Tested | — | Unavailable | | | 50 Confidence [VialVerse](https://peptidesupermarket.co.uk/suppliers/vialverse-2) Abaloparatide | £85.00 | £28.33/mg | In Stock | Free over £75 | Lab Tested | — | Visit | More ways to compare Abaloparatide Different views of the same live UK pricing, tuned for how you like to shop. [Best Abaloparatide Prices Best prices ranked](https://peptidesupermarket.co.uk/best-abaloparatide-prices) [Cheapest Abaloparatide Prices Cheapest suppliers compared](https://peptidesupermarket.co.uk/cheapest-abaloparatide-prices) [Where to Buy Abaloparatide Full buyer's guide](https://peptidesupermarket.co.uk/where-to-buy-abaloparatide) [Buy Abaloparatide Online UK Cheap Today's hottest deals](https://peptidesupermarket.co.uk/buy-abaloparatide-online-uk-cheap) [Abaloparatide Price Comparison Live price dashboard](https://peptidesupermarket.co.uk/abaloparatide-price-comparison) [Abaloparatide UK Supplier Verified UK supplier directory](https://peptidesupermarket.co.uk/abaloparatide-uk-supplier) [Abaloparatide For Sale Browse listings for sale](https://peptidesupermarket.co.uk/abaloparatide-for-sale) Compare another peptide Search PeptideSupermarket® compares prices but doesn't sell products. More All purchases are made directly from third-party suppliers; your relationship is solely with them. We accept no liability for the quality, purity, or legality of any products listed. We may earn a commission when you click through to a supplier and make a purchase. This does not affect pricing information displayed. By using this site you accept responsibility for ensuring purchases comply with applicable laws in your jurisdiction. [Read our full disclosure](https://peptidesupermarket.co.uk/disclosure). ## Abaloparatide Profile Extensively Studied FDA Approved PTHrP Analog | Anabolic Bone-Building Agent ### Overview Abaloparatide is an FDA-approved anabolic bone-building agent and synthetic analog of parathyroid hormone-related protein (PTHrP). It selectively activates the PTH1 receptor to stimulate new bone formation while minimizing bone resorption. In the phase III ACTIVE trial, abaloparatide showed superior BMD increases at the hip compared to teriparatide, with substantial fracture risk reduction. It was approved in the US in 2017 and EU in 2022 for postmenopausal women and men with osteoporosis at high fracture risk. ### Mechanism of Action Abaloparatide works through selective activation of the parathyroid hormone 1 receptor (PTH1R), a G protein-coupled receptor expressed on osteoblasts and osteocytes. It preferentially binds to the RG (relaxed, G-protein-coupled) conformational state of PTH1R, which elicits a transient downstream cyclic AMP signaling response favoring anabolic bone formation over resorption. This selective binding pattern produces more bone-building activity with less hypercalcemic effect compared to native PTH. The result is increased cortical and trabecular bone volume, density, and improved microarchitecture. ### Key Benefits - FDA-approved for osteoporosis treatment - Actively builds new bone (anabolic mechanism) - Superior hip BMD gains vs teriparatide in trials - Reduces vertebral fracture risk significantly - Reduces nonvertebral fracture risk - Lower hypercalcemia risk than teriparatide - Works through selective PTH1R activation - Benefits seen within 6 months ### Quick Stats Typical Dose 80 mcg Frequency Once daily Cycle Duration Up to 2 years (lifetime maximum) Storage Refrigerate pre-filled pen at 2-8°C, do not freeze. Discard after 30 days even if medication remains ## Molecular Information Molecular Weight 3,960 Da Length 34 amino acids Type Synthetic PTHrP analog Half-Life ~1.7 hours ### Amino Acid Sequence `C174H299N56O49 - 41% homology to PTH(1-34), 76% homology to PTHrP(1-34)` ## Research Indications The following information is derived from published scientific literature and is provided for educational and research reference purposes only. It does not constitute medical advice, diagnosis, or treatment recommendations. These peptides are not approved for human use and are sold exclusively for in-vitro laboratory research. Osteoporosis (FDA-Approved) Bone Health Research ## Dosing Protocols ### injectable Abaloparatide is administered as a once-daily subcutaneous injection in the periumbilical (around the navel) region of the abdomen. It comes in pre-filled pen devices (Tymlos). Cumulative lifetime use is limited to 2 years due to theoretical osteosarcoma risk observed in rodent studies. A transdermal patch formulation is also in development. | Goal | Dose | Frequency | Route | | --- | --- | --- | --- | | Osteoporosis treatment | 80 mcg | Once daily | SubQ (periumbilical abdomen) | #### Key Tips - Convenient pre-filled pen device - Simple once-daily dosing - Well-established protocol - Transdermal patch in development Reconstitution Instructions ## Peptide Interactions #### Bisphosphonates (Alendronate) Synergistic ACTIVExtend trial showed sequential abaloparatide then alendronate maintained and extended bone benefits. #### Calcium/Vitamin D Synergistic Adequate calcium (500-1000mg) and vitamin D (400-800 IU) supplementation recommended during therapy. #### Teriparatide Avoid Do not use concurrently; both are PTH receptor agonists. Choose one or use sequentially. #### BPC-157 Compatible Different mechanisms; no known interactions. #### TB-500 Compatible Different mechanisms; no known interactions. ## What to Expect Month 1-3 Bone formation markers increase; initial BMD changes begin Month 3-6 Significant BMD increases at spine, hip, and femur Month 6-12 Continued bone density improvements; fracture risk reduction Month 12-18 Maximum benefits in ACTIVE trial; substantial fracture reduction Month 18-24 Transition to maintenance therapy (e.g., bisphosphonates) recommended ## Side Effects & Safety #### Common Side Effects - Hypercalciuria (high calcium in urine) - Dizziness - Nausea - Headache - Palpitations - Fatigue - Upper abdominal pain - Vertigo - Injection site reactions #### Monitoring - Serum calcium levels - Urine calcium (hypercalciuria common) - Bone mineral density testing - Treatment limited to 2 years maximum lifetime - Follow with antiresorptive therapy to maintain gains #### Stop Signs - Signs of hypercalcemia (confusion, fatigue, excessive thirst) - Persistent bone pain - Severe dizziness or fainting - Allergic reactions #### Contraindications - Paget's disease of bone - Prior external beam or implant radiation therapy to skeleton - Bone metastases or history of skeletal malignancies - Metabolic bone diseases other than osteoporosis - Pre-existing hypercalcemia - Pregnancy or nursing - Cumulative use exceeding 2 years lifetime ## Quality Checklist #### Good Signs - Clear, colorless solution - Pharmaceutical grade (Tymlos/Eladynos) - Proper cold chain maintained - Intact pen device - Within expiration date #### Warning Signs - Research-grade products lack FDA oversight - Temperature excursions may affect potency #### Bad Signs - Cloudy or discolored solution - Particulates visible - Exposed to freezing or high temperatures - Damaged pen device ## Research & References ### Key References 1. 2016 #### Effect of Abaloparatide vs Placebo on New Vertebral Fractures in Postmenopausal Women With Osteoporosis (ACTIVE Trial) JAMA · Miller PD, Hattersley G, Riis BJ, et al. Abaloparatide showed substantial reduction in vertebral fractures and greater BMD increases at spine, hip, and femur compared to placebo and teriparatide. 2. 2017 #### ACTIVExtend Trial: Abaloparatide Followed by Alendronate Mayo Clinic Proceedings · Cosman F, Miller PD, Williams GC, et al. 18 months abaloparatide followed by alendronate significantly reduced vertebral and nonvertebral fractures. 3. 2015 #### Phase 2 Dose-finding Study of BA058 in Postmenopausal Women Journal of Clinical Endocrinology and Metabolism · Leder BZ, O'Dea LS, Zanchetta JR, et al. Significant BMD increases at 40 and 80 mcg doses; abaloparatide showed superior anabolic effects on hips vs teriparatide. 4. 2017 #### Profile of Abaloparatide and Its Potential in Postmenopausal Osteoporosis Cureus · Tella SH, Kommalapati A, Correa R Abaloparatide preferentially binds RG conformational state of PTH1R, producing more anabolic bone effects. [Search PubMed for Abaloparatide](https://pubmed.ncbi.nlm.nih.gov/?term=%28%22Abaloparatide%22%20OR%20%22Tymlos%22%20OR%20%22Eladynos%22%20OR%20%22BA058%22%20OR%20%22BIM-44058%22%29) Research Library ## Abaloparatide research & guides Plain-English guides and study summaries from published literature. [View all 3](https://peptidesupermarket.co.uk/research/peptide/abaloparatide) ![Abaloparatide and Fracture Risk: Why Bone Density Gains Matter](https://peptidesupermarket.co.uk/storage/2583/conversions/01KN9GCW55B20M63VZSTVDHAKB-thumbnail.jpg) Guides 5 min ### Abaloparatide and Fracture Risk: Why Bone Density Gains Matter The value of abaloparatide is not only that it builds bone, but that it may help strengthen the very areas most vulnerable to osteoporotic fracture. Read article [Abaloparatide and Fracture Risk: Why Bone Density Gains Matter](https://peptidesupermarket.co.uk/research/abaloparatide-and-fracture-risk-why-bone-density-gains-matter) ![How Abaloparatide Works to Rebuild Bone](https://peptidesupermarket.co.uk/storage/2582/conversions/01KN9G9CXY1MYSMC1YNYCQ5PS8-thumbnail.jpg) Guides 5 min ### How Abaloparatide Works to Rebuild Bone Abaloparatide is often discussed as a bone-building treatment because it helps stimulate osteoblast activity and improve bone mineral density in key fracture-prone areas. Read article [How Abaloparatide Works to Rebuild Bone](https://peptidesupermarket.co.uk/research/how-abaloparatide-works-to-rebuild-bone) ![Can Abaloparatide Increase Bone Mineral Density Effectively?](https://peptidesupermarket.co.uk/storage/2581/conversions/01KN9G5XSQCB918RPDEPCAAQSG-thumbnail.jpg) Guides 4 min ### Can Abaloparatide Increase Bone Mineral Density Effectively? Abaloparatide is widely discussed as a bone-building treatment for osteoporosis, with strong interest in its ability to increase bone mineral density in the spine, hip and femoral neck. Read article [Can Abaloparatide Increase Bone Mineral Density Effectively?](https://peptidesupermarket.co.uk/research/can-abaloparatide-increase-bone-mineral-density-effectively) --- *Add `.md` to any page URL on peptidesupermarket.co.uk for its Markdown version. Index of the site: https://peptidesupermarket.co.uk/llms.txt - full text: https://peptidesupermarket.co.uk/llms-full.txt.*