--- title: "PE-22-28 Peptide UK - Compare Prices from 14 Suppliers - PeptideSupermarket®" description: "Compare PE-22-28 prices from 14 UK suppliers, from £29.90. Find the cheapest deals, read reviews and save money." url: "https://peptidesupermarket.co.uk/peptide/pe-22-28" site: "PeptideSupermarket®" country: "United Kingdom" --- [Home](https://peptidesupermarket.co.uk) › [Peptides](https://peptidesupermarket.co.uk/compare-peptide-prices-uk) › PE-22-28 Search # PE-22-28 Price Comparison Live prices from 14 UK suppliers, from £29.90, compared side by side so you never overpay. [Neuropeptides & sleep research](https://peptidesupermarket.co.uk/compare-peptide-prices-uk) We compare prices & may earn a commission. Includes a featured placement — not an endorsement. [Full disclosure](https://peptidesupermarket.co.uk/disclosure). Best Price £29.90 Average £50.90 Highest £179.20 You Could Save 83% 14 results 10mg Featured Supplier [Kensington Labs](https://peptidesupermarket.co.uk/suppliers/kensington-labs) PE-22-28 Out of Stock 10mg Lab Tested 50 Confidence £34.90 FREE delivery View Deal Compare 14 prices for PE-22-28. Cheapest: £29.90. Average: £50.90. | Compare | Supplier | Price | Price / mg | Stock | Delivery | Quality | Coupon | Visit | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | | 95 Confidence [Alpha Peptides®](https://peptidesupermarket.co.uk/suppliers/alpha-peptides) ★★★★★ 5.0 (4) PE-22-28 | £38.00 | £3.80/mg | In Stock | Free over £100 | Lab Tested | — | Visit | | | 95 Confidence [BioPlex Peptides](https://peptidesupermarket.co.uk/suppliers/bioplex-peptides) ★★★★★ 5.0 (1) PE-22-28 10mg (Spadin-TREK-1) | £42.99 | £4.30/mg | In Stock | Free | Lab Tested | — | Visit | | | 80 Confidence [Raccoon Peptides](https://peptidesupermarket.co.uk/suppliers/raccoon-peptides) Best ★★★★★ 5.0 (1) PE-22-28 | £29.90 | £2.99/mg | In Stock | Free | Lab Tested | — | Unavailable | | | 70 Confidence [RC Peptides](https://peptidesupermarket.co.uk/suppliers/rc-peptides) ★★★★★ 4.8 (176) PE-22-28 | £40.00 | £4.00/mg | In Stock | Free | Lab Tested | — | Visit | | | 68 Confidence [Woodlands Biohack](https://peptidesupermarket.co.uk/suppliers/woodlands-biohack) PE-22-28 10mg | £179.20 | £17.92/mg | In Stock | Free over £100 | Lab Tested | — | Visit | | | 64 Confidence [Union Biolabs](https://peptidesupermarket.co.uk/suppliers/union-biolabs) PE-22-28 10mg | £48.00 | £4.80/mg | In Stock | Free | Lab Tested | — | Visit | | | 50 Confidence [Be Better Peptides](https://peptidesupermarket.co.uk/suppliers/be-better-peptides) ★★★★★ 5.0 (1) PE-22-28 10mg | £29.99 | £3.00/mg | In Stock | Free | — | — | Visit | | | 50 Confidence [Biolabs](https://peptidesupermarket.co.uk/suppliers/biolabs) PE-22-28 10mg | £38.12 | £3.81/mg | In Stock | Free | — | — | Visit | | | 50 Confidence [Genopept](https://peptidesupermarket.co.uk/suppliers/genopept) PE-22-28 10mg | £39.00 | £3.90/mg | In Stock | Free over £200 | Lab Tested | — | Visit | | | 50 Confidence [Biolabshopuk](https://peptidesupermarket.co.uk/suppliers/biolabshopuk) PE-22-28 10mg | £39.99 | £4.00/mg | In Stock | Free | — | — | Unavailable | | | 50 Confidence [Biolabshopofficial](https://peptidesupermarket.co.uk/suppliers/biolabshopofficial) PE-22-28 10mg | £39.99 | £4.00/mg | In Stock | Free | — | — | Unavailable | | | 50 Confidence [NASS Peptides](https://peptidesupermarket.co.uk/suppliers/nass-peptides) PE-22-28 10mg | £52.50 | £5.25/mg | In Stock | Free | Lab Tested | — | Unavailable | | | 50 Confidence [Orbitrex Peptides](https://peptidesupermarket.co.uk/suppliers/orbitrex-peptides) PE-22-28 10mg | £59.99 | £6.00/mg | In Stock | Free | Lab Tested | — | Visit | More ways to compare PE-22-28 Different views of the same live UK pricing, tuned for how you like to shop. [Best PE-22-28 Prices Best prices ranked](https://peptidesupermarket.co.uk/best-pe-22-28-prices) [Cheapest PE-22-28 Prices Cheapest suppliers compared](https://peptidesupermarket.co.uk/cheapest-pe-22-28-prices) [Where to Buy PE-22-28 Full buyer's guide](https://peptidesupermarket.co.uk/where-to-buy-pe-22-28) [Buy PE-22-28 Online UK Cheap Today's hottest deals](https://peptidesupermarket.co.uk/buy-pe-22-28-online-uk-cheap) [PE-22-28 Price Comparison Live price dashboard](https://peptidesupermarket.co.uk/pe-22-28-price-comparison) [PE-22-28 UK Supplier Verified UK supplier directory](https://peptidesupermarket.co.uk/pe-22-28-uk-supplier) [PE-22-28 For Sale Browse listings for sale](https://peptidesupermarket.co.uk/pe-22-28-for-sale) Compare another peptide Search PeptideSupermarket® compares prices but doesn't sell products. More All purchases are made directly from third-party suppliers; your relationship is solely with them. We accept no liability for the quality, purity, or legality of any products listed. We may earn a commission when you click through to a supplier and make a purchase. This does not affect pricing information displayed. By using this site you accept responsibility for ensuring purchases comply with applicable laws in your jurisdiction. [Read our full disclosure](https://peptidesupermarket.co.uk/disclosure). ## PE-22-28 Profile Emerging TREK-1 Channel Blocker | Shortened Spadin Analog ### Overview Synthetic heptapeptide derived from Spadin positions 22-28, functioning as potent TREK-1 antagonist with enhanced selectivity and duration versus parent compound. Primary research focus on rapid antidepressant effects. ### Mechanism of Action Selectively blocks TREK-1 potassium channels (IC50: 0.12 nM). Enhances serotonin neurotransmission in dorsal raphe nucleus, triggering CREB activation and hippocampal neurogenesis. ### Key Benefits - Rapid antidepressant effects within 4 days (preclinical) - Hippocampal neurogenesis and synaptogenesis - Enhanced serotonergic neurotransmission - Extended ~23 hour duration of action - 300-500x greater potency than full-length Spadin ### Quick Stats Typical Dose 50-200mcg daily Frequency Once daily Cycle Duration 4-8 weeks Storage Refrigerate at 2-8°C, use within 4-6 weeks ## Molecular Information Molecular Weight 773.89 Da Length 7 amino acids Type Linear heptapeptide Half-Life Approximately 23 hours ### Amino Acid Sequence One-letter: `GVSWGL?` Gly 1 Glycine Position 1 Val 2 Valine Position 2 Ser 3 Serine Position 3 Trp 4 Tryptophan Position 4 Gly 5 Glycine Position 5 Leu 6 Leucine Position 6 Arg 7 Arg (GVSWGLR) Position 7 N-terminus C-terminus Hydrophobic Polar Positive (+) Negative (-) Modified ### Modifications Derived from Spadin (PE 12-28) positions 22-28 ## Research Indications The following information is derived from published scientific literature and is provided for educational and research reference purposes only. It does not constitute medical advice, diagnosis, or treatment recommendations. These peptides are not approved for human use and are sold exclusively for in-vitro laboratory research. Mental Health Neurogenesis Cognition ## Dosing Protocols ### injectable Subcutaneous injection to abdominal fat or thigh with site rotation. | Goal | Dose | Frequency | Route | | --- | --- | --- | --- | | Antidepressant Effect | 50-200mcg | Once daily | SubQ | | Neurogenesis Support | 100-200mcg | Once daily | SubQ | #### Key Tips - Precise dosing - Rapid absorption - Extended duration (~23 hours) Reconstitution Instructions ### oral Limited data from animal studies only; higher doses required than injection. | Goal | Dose | Frequency | Route | | --- | --- | --- | --- | | General Use | Higher than injectable (specific dose TBD) | Daily | Oral | #### Key Tips - Non-invasive - Convenient - Limited bioavailability data ### nasal Theoretical route; unstudied for PE-22-28 specifically. | Goal | Dose | Frequency | Route | | --- | --- | --- | --- | | General Use | 100-300mcg (estimated) | Daily | Intranasal | #### Key Tips - Potential direct CNS access - Non-invasive ## Peptide Interactions #### SSRIs (Fluoxetine, Sertraline) Monitor Both enhance serotonergic pathways; monitor for excessive activity. #### Semax/NA-Semax Synergistic Complementary neurogenesis and cognitive support. #### Selank Synergistic Different mechanisms for anxiety and mood support. #### Dihexa Synergistic Complementary neuroplasticity pathways. #### BPC-157 Compatible Different mechanisms, no contraindications. #### MAOIs Avoid Serotonin syndrome risk. ## What to Expect Days 1-4 Measurable antidepressant effects in preclinical models Weeks 1-2 Neurogenesis and synaptogenesis processes established Weeks 2-4 Potential mood and cognitive improvements emerge Weeks 4-8 Sustained treatment allows full neurogenic effects ## Side Effects & Safety #### Common Side Effects - No effects on TREK-2, TRAAK, TASK-1 channels observed - No cardiac dysfunction or seizures in preclinical studies #### Monitoring - Research compound only - not FDA-approved - Unknown long-term human effects - Monitor for serotonin syndrome if combined with serotonergic medications #### Stop Signs - Serotonin syndrome signs - Severe persistent headaches - Cardiac symptoms - Seizure activity - Severe mood changes or suicidal ideation #### Contraindications - Pregnancy and breastfeeding - Concurrent MAOI use ## Quality Checklist #### Good Signs - White to off-white lyophilized powder - Clear, colorless reconstituted solution - Certificate of Analysis with >98% purity - Proper cold-chain shipping #### Warning Signs - Research compound only, not FDA-approved - Quality varies by supplier #### Bad Signs - Cloudy, discolored, or particulate appearance - Clumped or sticky powder indicating moisture damage ## Research & References ### Key References 1. 2017 #### Shortened Spadin Analogs Display Better TREK-1 Inhibition PE-22-28 IC50 0.12 nM vs 40-60 nM for Spadin; ~23 hour duration. Frontiers in Pharmacology. 2. 2010 #### Spadin: A Sortilin-Derived Peptide Targeting TREK-1 Channels Original discovery of TREK-1 blockade as antidepressant mechanism. PLOS Biology. 3. 2006 #### TREK-1 Deletion Results in Depression-Resistant Phenotype TREK-1 knockout mice show depression-resistant behavior in 5 tests. Nature Neuroscience. [Search PubMed for PE-22-28](https://pubmed.ncbi.nlm.nih.gov/?term=%28%22PE-22-28%22%20OR%20%22Spadin%20Analogue%20PE-22-28%22%20OR%20%22Mini-Spadin%22%29) --- *Add `.md` to any page URL on peptidesupermarket.co.uk for its Markdown version. Index of the site: https://peptidesupermarket.co.uk/llms.txt - full text: https://peptidesupermarket.co.uk/llms-full.txt.*