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£94.00
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£114.50
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£115.00
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£119.99
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Tirzepatide 30mg

£140.00
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Tirzepatide 40mg

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Tirzepatide 50mg

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£149.99
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Tirzepatide 20mg

£149.99
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£150.00
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Tirzepatide 60mg

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Tirzepatide

£189.99
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Tirzepatide

£199.00
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Tirzepatide 40mg

£199.00
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Tirzepatide 60mg

£199.99
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Tirzepatide 60mg

£215.00
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Tirzepatide 40mg

£219.99
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Peptides Lab UK logo

Tirzepatide

£239.00
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Peptides Lab UK logo

Tirzepatide

£279.00
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Tirzepatide 120mg

£320.00
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Tirzepatide Profile

Fda Approved FDA Approved

Dual GIP/GLP-1 Receptor Agonist | Weight Loss & Diabetes

Overview

Revolutionary dual receptor agonist FDA-approved for type 2 diabetes and chronic weight management. Demonstrates efficacy superior to single-mechanism alternatives with 15-22% body weight reduction in clinical trials. The first-in-class dual GIP/GLP-1 agonist provides enhanced metabolic benefits compared to GLP-1-only medications.

Mechanism of Action

Dual agonist targeting both GIP and GLP-1 receptors, producing glucose-dependent insulin stimulation, delayed gastric emptying, glucagon suppression, and central satiety signaling via hypothalamic pathways.

Key Benefits

  • Dramatic weight loss (15-22% body weight)
  • Superior diabetes control
  • Reduced cardiovascular risk (26% reduction in MACE)
  • Improved insulin sensitivity
  • Appetite suppression
  • Preserved muscle mass with exercise

Quick Stats

Typical Dose
2.5mg starting, titrate up to 5-15mg weekly
Frequency
Once weekly (same day each week)
Cycle Duration
Ongoing therapy as prescribed
Storage
Pen: 2-8°C before first use, room temp up to 21 days after. Compounded: 2-8°C

Molecular Information

Molecular Weight
4,813.55 Da
Length
39 amino acids
Type
Dual GLP-1/GIP agonist
Half-Life
~5 days (120 hours)

Amino Acid Sequence

One-letter: HUEGTFTSDVSSYLEGQAAKEFIAWLVRGRGGGGGPSKKKKKK
His
1

Histidine

Position 1

Aib
2

Aminoisobutyric Acid

Position 2

Glu
3

Glutamic Acid

Position 3

Gly
4

Glycine

Position 4

Thr
5

Threonine

Position 5

Phe
6

Phenylalanine

Position 6

Thr
7

Threonine

Position 7

Ser
8

Serine

Position 8

Asp
9

Aspartic Acid

Position 9

Val
10

Valine

Position 10

Ser
11

Serine

Position 11

Ser
12

Serine

Position 12

Tyr
13

Tyrosine

Position 13

Leu
14

Leucine

Position 14

Glu
15

Glutamic Acid

Position 15

Gly
16

Glycine

Position 16

Gln
17

Glutamine

Position 17

Ala
18

Alanine

Position 18

Ala
19

Alanine

Position 19

Lys
20

Lysine

Position 20

Glu
21

Glutamic Acid

Position 21

Phe
22

Phenylalanine

Position 22

Ile
23

Isoleucine

Position 23

Ala
24

Alanine

Position 24

Trp
25

Tryptophan

Position 25

Leu
26

Leucine

Position 26

Val
27

Valine

Position 27

Arg
28

Arginine

Position 28

Gly
29

Glycine

Position 29

Arg
30

Arginine

Position 30

Gly
31

Glycine

Position 31

Gly
32

Glycine

Position 32

Gly
33

Glycine

Position 33

Gly
34

Glycine

Position 34

Gly
35

Glycine

Position 35

Pro
36

Proline

Position 36

Ser
37

Serine

Position 37

Lys
38

Lysine

Position 38

Lys
39

Lysine

Position 39

Lys
40

Lysine

Position 40

Lys
41

Lysine

Position 41

Lys
42

Lysine

Position 42

Lys
43

Lysine

Position 43

N-terminus C-terminus
Hydrophobic
Polar
Positive (+)
Negative (-)
Modified

Modifications

C20 fatty diacid conjugation for albumin binding

Research Indications

The following information is derived from published scientific literature and is provided for educational and research reference purposes only. It does not constitute medical advice, diagnosis, or treatment recommendations. These peptides are not approved for human use and are sold exclusively for in-vitro laboratory research.

Severe Obesity Management

Most Effective

Clinical trials demonstrate 15-22% body weight reduction in non-diabetic obese individuals, superior to existing weight loss medications.

Metabolic Syndrome Reversal

Most Effective

Improvements in waist circumference, blood pressure, triglycerides, HDL cholesterol, and insulin resistance markers.

Body Composition Optimization

Effective

Preferentially reduces visceral adipose tissue while preserving lean muscle mass with resistance training.

Type 2 Diabetes Management

Most Effective

Superior HbA1c reduction of 1.5-2.4% in clinical trials.

Insulin Resistance Improvement

Effective

Improves insulin sensitivity across diverse populations.

Beta Cell Preservation

Effective

May help preserve and restore pancreatic beta cell function.

MACE Reduction

Effective

26% reduction in major adverse cardiovascular events demonstrated in SURPASS-CVOT trial.

Blood Pressure Reduction

Effective

Systolic and diastolic blood pressure reductions of 8-12 mmHg.

Lipid Profile Improvement

Moderate

Triglyceride improvements of 20-30%, HDL enhancement, and apolipoprotein B reduction.

Dosing Protocols

injectable

Once-weekly subcutaneous injection. Can be taken any time of day, with or without food. Injection sites include thigh, abdomen (2+ inches from navel), or upper arm.

Goal Dose Frequency Route
Weight loss initiation 2.5mg Once weekly x 4 weeks SubQ injection
Weight loss progression 5mg Once weekly SubQ injection
Weight loss optimization 7.5-10mg Once weekly SubQ injection
Maximum weight loss 12.5-15mg Once weekly SubQ injection
Diabetes management (mild) 5-7.5mg Once weekly SubQ injection
Diabetes management (severe) 10-15mg Once weekly SubQ injection

Key Tips

  • Same day each week, any time of day
  • With or without food
  • Rotate injection sites weekly
Materials Needed
Tirzepatide lyophilized powder vial (or pre-filled pen) Bacteriostatic water for injection Insulin syringes (0.5ml or 1ml with fine needle) Alcohol prep pads Sterile work surface
Steps
  1. 1 Allow vial to reach room temperature (15-20 minutes)
  2. 2 Clean vial tops with alcohol wipes, allow air drying
  3. 3 Calculate reconstitution volume
  4. 4 Draw bacteriostatic water carefully into syringe
  5. 5 Insert needle at 45-degree angle against glass wall
  6. 6 Inject water slowly down vial side to prevent foaming
  7. 7 Gently swirl—never shake vigorously
  8. 8 Allow 2-3 minutes for clearing if cloudiness appears
  9. 9 Final solution must be completely clear and colorless
  10. 10 Label with date and concentration
  11. 11 Store at 2-8°C, use within 28 days

Peptide Interactions

Semaglutide

Avoid

Both are GLP-1 agonists—combining increases hypoglycemia and severe GI side effect risk.

Liraglutide

Avoid

Another GLP-1 agonist—dual therapy contraindicated due to additive effects.

Insulin

Monitor

May require significant insulin dose reduction due to improved sensitivity.

Metformin

Synergistic

Complementary mechanisms for diabetes management and weight loss.

CJC-1295

Compatible

Growth hormone support may help preserve muscle mass during weight loss.

Ipamorelin

Compatible

May help maintain metabolic rate and muscle preservation.

BPC-157

Compatible

No known interactions, may support gut health and reduce GI effects.

5-Amino-1MQ

Compatible

NNMT inhibition may complement GLP-1 effects for metabolic optimization.

What to Expect

Day 1-3

Appetite reduction begins

Week 1-2

Improved blood sugar control (diabetics), mild nausea common

Week 2-4

Initial weight loss begins; GI side effects typically improve

Ongoing

1-3 lbs weight loss per week during active phase

Week 16-24

Peak weight loss effects observed

Side Effects & Safety

Common Side Effects

  • Nausea (mild to moderate, first 2-4 weeks)
  • Appetite reduction
  • Possible fatigue during adaptation
  • Diarrhea or constipation
  • Reduced food cravings

Monitoring

  • Start with lowest dose (2.5mg) and escalate every 4 weeks
  • May require diabetes medication adjustment to prevent hypoglycemia
  • Monitor for pancreatitis symptoms

Stop Signs

  • Severe/persistent abdominal pain (pancreatitis risk)
  • Neck lumps, hoarseness, difficulty swallowing (thyroid concerns)
  • Severe nausea/vomiting preventing adequate nutrition
  • Severe hypoglycemic signs (confusion, sweating, rapid heartbeat)
  • Kidney problems (decreased urination, swelling)
  • Severe allergic reactions (rash, breathing difficulty)
  • Suicidal thoughts or severe depression
  • Gallbladder problems (severe upper right pain)
  • Dehydration from persistent vomiting

Contraindications

  • Personal or family history of medullary thyroid carcinoma
  • Multiple Endocrine Neoplasia syndrome type 2 (MEN2)
  • Pregnancy or breastfeeding
  • History of pancreatitis

Quality Checklist

Good Signs

  • White to off-white lyophilized powder without clumping
  • Clear, colorless reconstituted solution
  • Intact vial seal with visible mg dosage labeling and batch numbers
  • Proper storage maintenance at 2-8°C, protected from light

Warning Signs

  • Compounded versions without proper quality control

Bad Signs

  • Powder clumping, discoloration, or yellow/brown appearance
  • Persistent cloudiness after reconstitution
  • Unusual crystallization patterns

Research & References

Key References

2022

SURMOUNT-1 Phase 3 Trial

2,539 adults with obesity participants

15mg weekly achieved 22.5% weight loss vs 2.4% placebo over 72 weeks—largest weight loss in pharmaceutical trials.

2021-2022

SURPASS Clinical Program

13,000+ T2DM patients participants

Superior HbA1c reduction and weight loss compared to insulin, semaglutide, and existing diabetes medications.

2023

SURMOUNT-2 T2DM Trial

938 adults with T2DM and obesity participants

15mg dose achieved 15.7% weight loss with significant cardiometabolic improvements over 72 weeks.

2023

SURPASS-CVOT Cardiovascular Outcomes

12,785 T2DM patients over 3.5 years participants

26% reduction in major adverse cardiovascular events, establishing cardioprotective benefits.

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