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Compare 1 price for Aicar. Cheapest: £39.00. Average: £39.00.
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| £39.00 | £19.50/mg | In Stock | Free |
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5-Aminoimidazole-4-carboxamide Ribonucleotide | AMPK Activator
AICAR is a cell-permeable nucleoside analog that activates AMP-activated protein kinase (AMPK), a key regulator of cellular energy homeostasis. Originally studied for cardiac ischemia protection, it gained attention as an 'exercise mimetic' due to its metabolic effects.
Once inside cells, AICAR is phosphorylated to ZMP, which mimics AMP and activates AMPK. This triggers metabolic pathways typically activated during exercise: increased glucose uptake, fatty acid oxidation, and mitochondrial biogenesis.
Directly activates the master metabolic regulator through ZMP accumulation.
Increases fat burning through AMPK-mediated pathways.
Enhances glucose uptake independent of insulin in some tissues.
Animal studies showed increased running endurance; human data limited.
AMPK activation promotes new mitochondria formation over time.
Original clinical interest; may protect heart tissue during reduced blood flow.
Subcutaneous injection once daily. Progressive dosing protocols are common to assess tolerance.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Standard Protocol | 1-3mg | Daily | SubQ |
| Gradual Introduction | 1mg → 2mg → 3mg | Daily, titrating over 4 weeks | SubQ |
| Advanced Protocol | 3-5mg | Daily for 8-12 weeks | SubQ |
Both activate AMPK through different mechanisms. Combined use may have additive effects on glucose metabolism.
Different pathways (AMPK vs PPARδ) that may complement metabolic effects. Popular research combination.
Rev-ErbA agonist with complementary metabolic effects.
Subtle changes in energy levels; body adjusting to AMPK activation
Potential improvements in endurance capacity and metabolic markers
Cumulative metabolic adaptations; enhanced fat oxidation
Full effects on mitochondrial density and metabolic efficiency
Review of AMPK role in exercise-induced metabolic adaptations and AICAR as pharmacological activator.
Mice treated with AICAR showed 44% increase in running endurance without training.
Plain-English guides and study summaries from published literature.
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