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Compare 4 prices for DSIP. Cheapest: £10.00. Average: £35.99.
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| £17.95 | £8.98/mg | Out of Stock | Free |
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| £10.00 | £5.00/mg | Low Stock | Free over £200 |
Lab Tested
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| £20.99 | £10.50/mg | In Stock | Free |
Lab Tested
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| £95.00 | £47.50/mg | In Stock | £9.99 |
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Delta Sleep-Inducing Peptide | Sleep & Stress Modulator
DSIP is a naturally occurring nonapeptide discovered in 1974 in rabbit brain. Originally isolated for sleep-promoting properties, it has diverse neuromodulatory effects including stress reduction, pain modulation, and endocrine regulation without traditional sedative effects.
Modulates multiple neurotransmitter systems including GABA enhancement, NMDA receptor interaction, and endogenous opioid system modulation. Also regulates hypothalamic-pituitary-adrenal axis for stress response.
WAGGDASGE
Tryptophan
Position 1
Alanine
Position 2
Glycine
Position 3
Glycine
Position 4
Aspartic Acid
Position 5
Alanine
Position 6
Serine
Position 7
Glycine
Position 8
Glutamic Acid
Position 9
Promotes delta wave sleep, the most restorative sleep phase for physical recovery.
Reduces sleep latency and nocturnal awakenings without morning grogginess.
Supports natural sleep cycles rather than forcing sedation like traditional sleep aids.
Helps regulate cortisol and stress response through HPA axis modulation.
Supports emotional balance without sedation.
May help reduce anxiety through neuromodulatory effects.
Significantly reduced pain levels in 6 of 7 patients with chronic pain conditions.
Helps manage withdrawal symptoms in alcohol and opioid-dependent patients.
Supports post-training recovery through enhanced sleep quality.
Subcutaneous injection is the standard route. Best taken 30-60 minutes before bedtime. Some prefer earlier evening dosing for gradual onset.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Sleep enhancement | 100-200mcg | Once nightly | SubQ |
| Chronic pain support | 250-300mcg | Daily | SubQ or IV |
| Stress management | 150mcg | Evening | SubQ |
| Withdrawal support | 200-300mcg | Twice daily | IV preferred |
| Athletic recovery | 100-150mcg | Post-training | SubQ |
Intranasal spray offers convenient administration with limited stability data.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Sleep induction | 200-300mcg | Once at bedtime | Nasal spray |
| Stress relief | 150-200mcg | Twice daily | Nasal spray |
| Neuroprotection | 300-400mcg | Daily | Nasal spray |
Both regulate sleep-wake cycles; complementary benefits.
DSIP enhances GABA - watch for excessive sedation.
Can combine for comprehensive stress management.
Complementary anxiolytic effects.
Different mechanisms; can optimize 24-hour function.
May modulate opioid receptors; requires professional supervision.
No direct interaction; DSIP may support natural GH release during sleep.
Both support circadian regulation and sleep quality.
Noticeable sleep pressure and easier sleep onset
Deeper sleep, fewer awakenings, vivid dreams possible
Improved morning refreshment, stable daytime energy
Cumulative stress reduction, mood improvements
Benefits may persist 1-2 weeks after stopping
Neuropeptide Research
Comprehensive review of DSIP's stress-protective mechanisms over four decades of research.
Drug Delivery Research
Enhanced intranasal delivery methods for improved bioavailability.
Neuroscience and biobehavioral reviews · Graf MV, Kastin AJ
This review summarized early biochemical, pharmacologic, and sleep-related findings on DSIP and highlighted unresolved questions about its endogenous role.
European journal of anaesthesiology · Pollard BJ, Pomfrett CJ
This review discussed early evidence for DSIP-like activity, proposed physiologic roles, and the variability of reported effects across experimental systems.
Plain-English guides and study summaries from published literature.
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