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Gonadorelin 2mg
Gonadorelin
Compare 5 prices for Gonadorelin. Cheapest: £12.38. Average: £44.37.
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| £112.00 | £56.00/mg | In Stock | Free over £100 |
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| £12.38 | £6.19/mg | In Stock | Free |
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| £22.00 | £11.00/mg | Low Stock | Free over £200 |
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| £32.50 | £16.25/mg | In Stock | Free |
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| £42.99 | £21.50/mg | In Stock | Free |
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Gonadotropin-Releasing Hormone | GnRH Agonist
Gonadorelin is a synthetic form of the naturally occurring gonadotropin-releasing hormone (GnRH). It stimulates the pituitary gland to release follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which in turn regulate testosterone production in men and ovulation in women. It is FDA-approved for diagnostic testing and fertility treatment. The pulsatile nature of GnRH secretion is critical for proper reproductive function.
Gonadorelin acts as an agonist of the GnRH receptor in the anterior pituitary. When administered in pulses (mimicking natural secretion patterns every 60-120 minutes), it stimulates release of FSH and LH. LH then stimulates Leydig cells in the testes to produce testosterone, or triggers ovulation in women. Continuous exposure paradoxically causes receptor downregulation and suppressed hormone production.
?HWSYGLRPG?
pGlu
Position 1
Histidine
Position 2
Tryptophan
Position 3
Serine
Position 4
Tyrosine
Position 5
Glycine
Position 6
Leucine
Position 7
Arginine
Position 8
Proline
Position 9
Glycine
Position 10
NH2
Position 11
Treatment of conditions like Kallmann syndrome where GnRH deficiency causes low testosterone and infertility.
Induces ovulation in women with hypothalamic amenorrhea who don't ovulate regularly.
Stimulates testosterone and sperm production by restoring LH/FSH pulsatility.
Treatment of delayed puberty due to hypothalamic-pituitary dysfunction.
Used to assess hypothalamic-pituitary function and diagnose GnRH deficiency.
Evaluates pituitary reserve and responsiveness to GnRH stimulation.
Maintains testicular function and fertility during testosterone replacement therapy.
Helps restore natural testosterone production after anabolic steroid use.
Treatment of undescended testes in pediatric patients.
Can be administered as single injections or via pulsatile infusion pump. Single injections are used for diagnostic testing, while pulsatile administration mimics natural GnRH secretion for therapeutic purposes. Very short half-life (10-40 minutes) requires careful dosing strategy.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Diagnostic testing | 100 mcg | Single injection | SubQ or IV |
| Fertility support | 50-100 mcg | 2-3x weekly | SubQ |
| Pulsatile therapy | 5-20 mcg per pulse | Every 90-120 min | SubQ pump |
| TRT adjunct | 100-200 mcg | 2-3x weekly | SubQ |
Nasal spray formulation available in some regions for convenience of administration.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Hormone support | As prescribed | Per protocol | Intranasal |
Often used as alternative to hCG for testicular stimulation during TRT.
Used alongside TRT to maintain testicular function and fertility.
Can be combined in fertility and PCT protocols.
Kisspeptin stimulates GnRH release; can work together for hormone optimization.
LH and FSH release begins
Testosterone increase in response to LH
Improved hormonal markers on blood tests
Restoration of natural hormone pulsatility
Maintained testicular function and fertility
Journal of Clinical Endocrinology & Metabolism
Pulsatile GnRH administration effectively restores fertility in patients with hypothalamic hypogonadism.
Frontiers in Endocrinology
Pulsatile GnRH secretion (every 60-120 min) is essential for proper FSH/LH release and reproductive function.
Fertility and Sterility
Effective treatment for ovulation induction in women with hypothalamic amenorrhea.
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