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HMG
Compare 9 prices for HMG. Cheapest: £32.50. Average: £49.81.
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| £134.40 | — | In Stock | Free over £100 |
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Human Menopausal Gonadotropin | FSH/LH Fertility Hormone
Human Menopausal Gonadotropin (HMG) is a hormonally active medication containing follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in a 1:1 ratio, extracted from the urine of postmenopausal women. FDA-approved for fertility treatment, HMG stimulates ovarian follicle development in women and spermatogenesis in men. While largely replaced by recombinant gonadotropins in some settings, HMG remains an effective and cost-efficient option for ovulation induction and assisted reproduction.
HMG acts on gonadal tissue through two mechanisms: FSH stimulates growth and maturation of ovarian follicles containing eggs in women, and promotes spermatogenesis in men. LH stimulates ovulation and corpus luteum formation in women, and Leydig cells in men to produce testosterone. Highly purified HMG (HP-hMG) has enhanced FSH receptor activity with reduced inactive proteins. The LH component modifies follicular development and decreases intermediate-sized follicles, potentially resulting in safer, more controlled stimulation.
Stimulates follicular development in anovulatory women.
Used in IVF protocols to stimulate multiple follicle development.
Effective for inducing ovulation in polycystic ovary syndrome patients.
FSH promotes sperm production; LH stimulates testosterone for sperm development.
Treats male infertility due to insufficient gonadotropin production.
LH component stimulates testicular testosterone production.
HMG is administered via intramuscular or subcutaneous injection. Treatment typically starts on day 2-3 of the menstrual cycle and continues for 7-12 days with monitoring. Dosing is individualized based on follicular response monitored by ultrasound and estradiol levels.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Ovulation induction | 75-150 IU | Daily | IM or SubQ |
| IVF stimulation | 150-300 IU | Daily for 7-12 days | IM or SubQ |
| Male fertility | 75-150 IU | 2-3x weekly | IM or SubQ |
hCG is typically used to trigger ovulation after HMG-induced follicular development.
Often used in combination protocols for IVF to prevent premature LH surge.
May be used in sequential protocols for ovulation induction.
Different mechanisms; may be used in different fertility protocols.
Follicular recruitment begins
Follicular growth continues; monitoring required
Follicles reach mature size; trigger ovulation
Ovulation occurs ~36 hours after hCG trigger
ScienceDirect
HMG contains FSH and LH in 1:1 ratio extracted from postmenopausal urine.
PMC/NCBI
No significant differences in pregnancy rates between FSH alone, rFSH+HMG, and rFSH+rLH groups.
Human Reproduction
Beneficial effects of HMG on fertilization rates and pre-embryo development compared to HP-FSH.
PubMed
Generic hMG products do not adversely affect pregnancy rates and are appropriate cost-effective alternatives.
Plain-English guides and study summaries from published literature.
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