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MGF 5mg
Compare 4 prices for MGF. Cheapest: £45.00. Average: £74.44.
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| £45.00 | £9.00/mg | In Stock | £9.99 |
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| £52.00 | £10.40/mg | In Stock | Free |
Lab Tested
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| £68.00 | £13.60/mg | In Stock | Free |
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| £132.75 | £26.55/mg | In Stock | £9.99 |
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Mechano Growth Factor | IGF-1 Splice Variant
Non-pegylated IGF-1 splice variant produced locally in muscle tissue following mechanical stress. Has a very short half-life compared to PEG-MGF, requiring more frequent administration or localized injection.
Activates muscle satellite stem cells via receptor binding, stimulating MAPK/ERK signaling. Enhances protein synthesis and promotes muscle fiber repair. The E-peptide domain exhibits distinct activity from mature IGF-1.
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Primary mechanism activating dormant muscle satellite cells which fuse to damaged fibers.
Short half-life means effects are concentrated at injection site.
Naturally upregulated after mechanical stress; supplementation enhances repair processes.
Animal studies suggest improved tendon injury outcomes when applied locally.
Research indicates potential for bone healing via osteoblast regulation.
Intramuscular injection directly into target muscle immediately post-workout for localized effects due to short half-life.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Standard Protocol | 100-300mcg | Daily, post-workout | IM into target muscle |
| Progressive Titration | 100mcg → 300mcg | Daily, increasing weekly | IM bilateral |
| Localized Recovery | 200-300mcg | Immediately post-workout | IM into worked muscle groups |
Same active peptide with different half-lives. Combining is redundant; choose one based on protocol preference.
Both target IGF-1 pathways; combining risks receptor overstimulation.
Complementary mechanisms. BPC-157 promotes angiogenesis; MGF activates satellite cells.
TB-500 reduces inflammation and promotes cell migration; MGF activates muscle stem cells.
Very short half-life means localized effects at injection site within minutes
Reduced muscle soreness in targeted areas; subtle recovery improvements
Improved recovery in targeted muscles; enhanced training capacity
The Journal of physiology · McKoy G, Ashley W, Mander J, Yang SY, Williams N, Russell B, Goldspink G
This study examined mechanically loaded rabbit skeletal muscle and reported induction of IGF-1 splice variants associated with stretch and electrical stimulation.
FEBS letters · Owino V, Yang SY, Goldspink G
This paper studied overloaded skeletal muscle in young and older rats and reported an age-associated reduction in the overload-induced MGF/IGF-1 splice-variant response.
The Journal of physiology · Hill M, Goldspink G
This rodent injury study linked local muscle damage with altered IGF-1 gene splicing and satellite-cell activation, including expression of the MGF-associated splice form.
Endocrinology · Matheny RW Jr, Nindl BC, Adamo ML
This review summarized evidence that an IGF-I splice variant termed mechano growth factor is induced by mechanical loading or tissue damage and may participate in local repair responses.
Physiology (Bethesda, Md.) · Goldspink G
This review discussed how mechanical stimuli regulate IGF-I alternative splicing in skeletal muscle, with emphasis on MGF expression during muscle adaptation.
In vivo (Athens, Greece) · Philippou A, Papageorgiou E, Bogdanis G, Halapas A, Sourla A, Maridaki M, Pissimissis N, Koutsilieris M
This study measured IGF-1 isoforms after exercise-induced muscle damage in humans and examined MGF E-peptide effects in cell-culture assays.
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