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Dual GLP-1/Glucagon Receptor Agonist | Weight Loss & Diabetes
Investigational dual receptor agonist targeting metabolic disease through balanced GLP-1R and GCGR activation. Phase 2/3 clinical trials demonstrate superior weight loss and MASH treatment efficacy.
Dual agonism: GLP-1R reduces appetite and slows gastric emptying; GCGR increases energy expenditure and hepatic fat oxidation. EC50 0.52nM GCGR, 0.33nM GLP-1R.
29-amino acid peptide
14.9% mean weight loss at 46 weeks (4.8mg); 55% achieved ≥15% reduction.
Superior to semaglutide: -8.7% vs -5.3% at 16 weeks.
Dual mechanism addresses both energy intake and expenditure.
62% achieved MASH improvement without fibrosis worsening at 4.8mg.
63-67% achieved ≥30% liver fat reduction.
HbA1c reduction up to -1.6% at highest doses.
Subcutaneous injection to abdomen (2+ inches from navel), upper thigh, or upper arm. Any time of day, with or without food.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Obesity - Conservative Start | 0.6mg titrated over 24 weeks | Once weekly with 4-week intervals | SubQ |
| Obesity - Standard Protocol | 3.6-6.0mg | Once weekly | SubQ |
| MASH Treatment | 2.4-4.8mg | Once weekly | SubQ |
| Type 2 Diabetes | 0.3-2.7mg | Once weekly | SubQ |
Both GLP-1 agonists; combining risks excessive activation and GI side effects.
Demonstrated together in Phase 2 diabetes trials.
No known interactions; allowed in Phase 3 with monitoring.
Hypoglycemia risk; consider dose reduction.
May require insulin dose reduction due to improved glycemic control.
Take 1+ hour before survodutide due to delayed gastric emptying.
Risk of excessive glucagon receptor activation.
Possible nausea, reduced appetite (most common during escalation)
Initial weight loss begins; improved satiety between meals
Progressive weight loss; potential energy level improvements
Approaching steady-state; more consistent effects
Sustained weight loss; average 15-19% by week 46
387 participants; BMI ≥27 kg/m²; 46 weeks. 14.9% mean weight loss at 4.8mg; 83% achieved ≥5%, 69% achieved ≥10%, 55% achieved ≥15%.
293 participants with biopsy-confirmed MASH; 48 weeks. MASH improvement: 62% (4.8mg) vs 14% placebo; 63-67% achieved ≥30% liver fat reduction.
Head-to-head vs semaglutide 1.0mg; 16 weeks. Survodutide -8.7% weight loss vs semaglutide -5.3%; HbA1c reduction up to -1.6%.
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