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Compare 1 price for 5-Amino 1MQ. Cheapest: £40.00. Average: £40.00.
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| £40.00 | — | In Stock | Free |
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NNMT Inhibitor | Longevity & Metabolic Enhancement
5-Amino-1MQ is a small molecule NNMT (nicotinamide N-methyltransferase) inhibitor that enhances cellular NAD+ levels and mitochondrial function. Not a true peptide, but a small molecule compound used in longevity and metabolic optimization protocols.
Inhibits NNMT enzyme systemically, preventing NAD+ degradation and maintaining elevated cellular NAD+ levels to support mitochondrial function and metabolic processes.
Significantly increases cellular NAD+ levels by inhibiting NNMT enzyme, supporting cellular energy production and DNA repair mechanisms essential for healthy aging.
Improves mitochondrial biogenesis and efficiency, enhancing cellular energy production and reducing oxidative stress markers associated with aging.
Enhanced NAD+ availability supports sirtuins and other longevity pathways involved in DNA repair, cellular maintenance, and stress resistance.
Improvement through enhanced mitochondrial efficiency.
Enhancement via cellular energy optimization.
Improved glucose/fat substrate switching.
Supports increased basal metabolic rate.
Improvements in fat burning capacity.
Most common delivery method. Take with food to improve absorption and reduce potential GI effects. Consistent daily timing helps maintain steady NAD+ levels. Morning or early afternoon dosing preferred.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Conservative initiation | 25mg | 1x daily | Oral with food |
| Standard starting dose | 50mg | 1x daily | Oral with food |
| Typical maintenance | 75mg | 1x daily | Oral with food |
| Maximum dose | 100mg | 1x daily | Oral with food |
| Split dosing protocol | 50mg | 2x daily | Oral with meals |
Injectable protocols exist but vary widely. CRITICAL: Two vastly different protocols exist differing by 100-200x depending on units (mcg vs mg). Verify units before use.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Conservative starting (mcg protocol) | 150-250mcg | 1x daily | SubQ |
| Conservative standard (mcg protocol) | 250-500mcg | 1x daily | SubQ |
| Study-based (mg protocol) | ~350mg (5mg/kg) | 1x daily | SubQ |
May work synergistically by preventing breakdown while supporting production.
Both support longevity; resveratrol activates sirtuins while 5-Amino-1MQ provides NAD+ substrate.
Both affect metabolic pathways; combination may enhance effects but requires careful monitoring.
No known interactions; different mechanisms with potential complementary benefits.
Limited interaction data; consult healthcare provider before combining.
Both affect metabolic pathways; potential additive glucose metabolism effects.
Gradual energy increase and mental clarity
Enhanced exercise performance and recovery
Improved metabolic markers and body composition
Sustained longevity benefits and cellular health improvements
Nature Reviews Drug Discovery
Comprehensive review of NNMT inhibition for metabolic disease and aging interventions.
Cell Metabolism
Role of NAD+ metabolism in healthy aging and therapeutic interventions.
Biochemical pharmacology · Neelakantan H, Vance V, Wetzel MD, Wang HL, McHardy SF, Finnerty CC, Hommel JD, Watowich SJ
This study identified 5-amino-1-methylquinolinium as a cell-permeable NNMT inhibitor and reported lower adiposity and altered NAD+/SAM-linked metabolism in high-fat-diet mouse experiments.
Biochemical pharmacology · Neelakantan H, Brightwell CR, Graber TG, Maroto R, Wang HL, McHardy SF, Papaconstantinou J, Fry CS, Watowich SJ
This study examined 5-amino-1MQ in aged skeletal-muscle models and found changes in muscle stem-cell function and regenerative readouts consistent with NNMT inhibition.
Nature chemical biology · Ulanovskaya OA, Zuhl AM, Cravatt BF
This mechanistic study reported that NNMT overexpression lowered cellular methyl-donor availability and reshaped histone methylation patterns in cancer-cell models.
Trends in endocrinology and metabolism: TEM · Pissios P
This review summarized NNMT biology, including its roles in nicotinamide metabolism, methyl-donor balance, metabolic disease models, and cancer biology relevant to NNMT inhibitors such as 5-amino-1MQ.
Plain-English guides and study summaries from published literature.
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