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Kisspeptin
Kisspeptin
Kisspeptin 5mg
Kisspeptin
Kisspeptin
Kisspeptin 5mg
Kisspeptin
Kisspeptin
Kisspeptin 5mg
Kisspeptin 5mg
Kisspeptin 5mg
Kisspeptin
Kisspeptin 5mg
Kisspeptin 5mg
Kisspeptin 5mg
Kisspeptin 5mg
Compare 52 prices for Kisspeptin. Cheapest: £13.00. Average: £27.18.
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| £18.99 | £3.80/mg | In Stock | Free |
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| £25.00 | £5.00/mg | In Stock | Free over £100 |
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| £19.99 | £4.00/mg | In Stock | Free |
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| £17.00 | £3.40/mg | In Stock | Free over £100 |
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| £21.95 | £4.39/mg | Out of Stock | Free over £75 |
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| £23.95 | £4.79/mg | Out of Stock | Free over £100 |
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| £19.99 | £4.00/mg | In Stock | Free over £75 |
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| £21.99 | £4.40/mg | In Stock | Free over £80 |
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| £23.95 | £4.79/mg | Out of Stock | Free |
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| £16.99 | £3.40/mg | In Stock | Free over £60 |
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| £112.00 | £22.40/mg | In Stock | Free over £100 |
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| £13.99 | £2.80/mg | In Stock | Free over £50 |
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| £15.00 | £3.00/mg | In Stock | Free |
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| £19.99 | £4.00/mg | In Stock | Free |
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| £25.00 | £5.00/mg | In Stock | Free |
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| £18.99 | £3.80/mg | In Stock | £9.99 |
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| £34.95 | £6.99/mg | In Stock | Free |
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| £13.00 | £2.60/mg | Out of Stock | £9.99 |
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| £18.95 | £3.79/mg | In Stock | £9.99 |
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| £19.90 | £3.98/mg | In Stock | Free |
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| £19.99 | £4.00/mg | In Stock | Free |
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| £20.00 | £4.00/mg | Out of Stock | £9.99 |
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| £20.99 | £4.20/mg | In Stock | Free over £50 |
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| £21.50 | £4.30/mg | In Stock | Free |
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| £23.95 | £4.79/mg | In Stock | Free |
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KISS1 Gene Product | Reproductive Neuropeptide
Kisspeptin acts as a master regulator of the reproductive system, stimulating GnRH neurons essential for puberty, fertility, and reproductive function.
Binds to GPR54/KISS1R receptors on hypothalamic GnRH neurons, triggering pulsatile GnRH release, which stimulates pituitary LH/FSH secretion and gonadal steroid production.
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Kisspeptin
Position 1
10: Tyr
Position 2
Asparagine
Position 3
Tryptophan
Position 4
Asparagine
Position 5
Serine
Position 6
Phenylalanine
Position 7
Glycine
Position 8
Leucine
Position 9
Arginine
Position 10
Phenylalanine
Position 11
NH2
Position 12
Restores reproductive hormone secretion in functional or congenital cases by stimulating dormant GnRH axis.
Triggers oocyte maturation with 45% live birth rate and zero severe OHSS cases; safer than hCG.
Restores reproductive hormone pulsatility in women with hypothalamic amenorrhea.
Modulates sexual brain processing; increases penile tumescence by 56% vs placebo.
Modulates sexual and attraction brain processing; increases self-reported sexiness.
Preclinical evidence suggests influence on energy expenditure and activity levels.
Standard administration route; allows precise dosing and rapid hormone stimulation.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Gonadotropin stimulation | 100-200mcg | Single dose or 2-3x weekly | SubQ |
| Fertility support | 0.4-1.0 nmol/kg (50-150mcg) | As directed by physician | SubQ (KP-54) |
| Sexual function (clinical) | 1 nmol/kg/h | 75-minute IV infusion | IV infusion |
Emerging non-invasive delivery method; 2025 research demonstrates effectiveness with stable formulations.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Gonadotropin stimulation (research) | 12.8 nmol/kg | Single dose | Intranasal |
Kisspeptin stimulates GnRH release; works upstream in reproductive axis.
Serves as potentially safer alternative for IVF ovulation triggering.
Restores natural testosterone production through LH stimulation.
Kisspeptin function modulated by sex steroids in feedback loops.
LH surge peaks at 3-5x baseline
LH returns to baseline
Testosterone/estradiol increase in response to LH
Potential improvements in sexual function and libido
Nature · Ohtaki T, Shintani Y, Honda S, Matsumoto H, Hori A, Kanehashi K, Terao Y, Kumano S, Takatsu Y, Masuda Y, Ishibashi Y, Watanabe T, Asada M, Yamada T, Suenaga M, Kitada C, Usuki S, Kurokawa T, Onda H, Nishimura O, Fujino M
This paper identified KiSS-1-derived peptides, including the 54-amino-acid peptide later termed kisspeptin-54 or metastin, as endogenous ligands for a G-protein-coupled receptor now known as KISS1R/GPR54.
The New England journal of medicine · Seminara SB, Messager S, Chatzidaki EE, Thresher RR, Acierno JS Jr, Shagoury JK, Bo-Abbas Y, Kuohung W, Schwinof KM, Hendrick AG, Zahn D, Dixon J, Kaiser UB, Slaugenhaupt SA, Gusella JF, O'Rahilly S, Carlton MB, Crowley WF Jr, Aparicio SA, Colledge WH
This human genetics study linked loss-of-function variants in GPR54/KISS1R with absent or incomplete pubertal development and hypogonadotropic hypogonadism.
Proceedings of the National Academy of Sciences of the United States of America · de Roux N, Genin E, Carel JC, Matsuda F, Chaussain JL, Milgrom E
This study reported families in which inactivating GPR54/KISS1R variants were associated with isolated hypogonadotropic hypogonadism, supporting a role for kisspeptin signaling in human reproductive endocrine regulation.
Proceedings of the National Academy of Sciences of the United States of America · Messager S, Chatzidaki EE, Ma D, Hendrick AG, Zahn D, Dixon J, Thresher RR, Malinge I, Lomet D, Carlton MB, Colledge WH, Caraty A, Aparicio SA
This mechanistic study found that kisspeptin acts through GPR54 to promote gonadotropin-releasing hormone release, placing kisspeptin signaling upstream of pituitary gonadotropin secretion.
Proceedings of the National Academy of Sciences of the United States of America · d'Anglemont de Tassigny X, Fagg LA, Dixon JP, Day K, Leitch HG, Hendrick AG, Zahn D, Franceschini I, Caraty A, Carlton MB, Aparicio SA, Colledge WH
This mouse knockout study showed that disruption of Kiss1 was associated with impaired sexual maturation, small gonads, and low gonadotropin levels.
The Journal of clinical endocrinology and metabolism · Dhillo WS, Chaudhri OB, Patterson M, Thompson EL, Murphy KG, Badman MK, McGowan BM, Amber V, Patel S, Ghatei MA, Bloom SR
This clinical study reported that administration of kisspeptin-54 to healthy men was followed by increases in circulating luteinizing hormone, follicle-stimulating hormone, and testosterone.
The Journal of clinical endocrinology and metabolism · Dhillo WS, Chaudhri OB, Thompson EL, Murphy KG, Patterson M, Ramachandran R, Nijher GK, Amber V, Kokkinos A, Donaldson M, Ghatei MA, Bloom SR
This study examined kisspeptin-54 administration across menstrual-cycle phases and observed the largest luteinizing-hormone response during the preovulatory phase.
Plain-English guides and study summaries from published literature.
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