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Mots-C 5mg
Mots-C 5mg
Compare 5 prices for Mots-C. Cheapest: £9.99. Average: £22.47.
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| £9.99 | £2.00/mg | Out of Stock | £9.99 |
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| £11.85 | £2.37/mg | In Stock | Free |
Lab Tested
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| £19.50 | £3.90/mg | In Stock | Free |
Lab Tested
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| £25.00 | £5.00/mg | In Stock | Free |
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| £46.00 | £9.20/mg | In Stock | Free |
Lab Tested
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Mitochondrial-Derived Peptide | Metabolic Regulator
MOTS-c is a mitochondrial-derived peptide that operates as a mitohormone through the Folate-AICAR-AMPK pathway. Under metabolic stress, it translocates to the nucleus to bind stress-response transcription factors (NRF2, ATF1/ATF7), regulating genes involved in metabolism and cellular adaptation.
Inhibits the folate cycle leading to AMPK activation. Under metabolic stress, translocates to nucleus to bind stress-response transcription factors, regulating genes involved in metabolism, insulin sensitivity, and cellular adaptation.
MRWQEMGYIFYPRKLR
Methionine
Position 1
Arginine
Position 2
Tryptophan
Position 3
Glutamine
Position 4
Glutamic Acid
Position 5
Methionine
Position 6
Glycine
Position 7
Tyrosine
Position 8
Isoleucine
Position 9
Phenylalanine
Position 10
Tyrosine
Position 11
Proline
Position 12
Arginine
Position 13
Lysine
Position 14
Leucine
Position 15
Arginine
Position 16
Improves insulin sensitivity by ~30% in animal studies through AMPK activation.
Restores metabolic function via insulin receptor sensitization.
Promotes fatty acid oxidation despite identical caloric intake.
Reverses age-dependent physical decline in animal models.
Enhances mitochondrial function via PGC-1α activation.
6.4% median lifespan extension observed in mice studies.
12-15% improvement in running performance from single dose in studies.
Exercise induced 11.9-fold increase in skeletal muscle MOTS-c.
Supports muscle recovery and adaptation to exercise.
Subcutaneous injection is the primary route. Optimal administration is morning before exercise. AMPK activation occurs within 30 minutes.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Metabolic health | 5-10mg | Once daily | SubQ |
| Anti-aging protocol | 15mg | 3x weekly | SubQ |
| Exercise performance | 10-15mg | Pre-workout | SubQ |
| Conservative start | 5mg | Once daily | SubQ |
Both activate AMPK; monitor for additive hypoglycemic effects.
Complementary mitochondrial enhancement through different pathways.
Different mechanisms allow safe combination.
Both are AMPK activators; monitor for additive effects.
Complementary SIRT1/AMPK activation pathways.
May require dose adjustments to prevent hypoglycemia.
AMPK pathway activation; initial glucose tolerance improvements
Enhanced exercise capacity; improved insulin sensitivity
Sustained metabolic benefits; potential body composition changes
Maximum mitochondrial function enhancement; metabolic flexibility
Ophthalmology Research
Dose-dependent protective effects on retinal cells in AMD models.
Cell metabolism · Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, Kim SJ, Mehta H, Hevener AL, de Cabo R, Cohen P
This foundational study identified MOTS-c as a peptide encoded within mitochondrial 12S rRNA and reported effects on cellular folate-cycle metabolism, AMPK signaling, body-weight gain, and insulin-sensitivity measures in mouse metabolic models.
Nature communications · Reynolds JC, Lai RW, Woodhead JST, Joly JH, Mitchell CJ, Cameron-Smith D, Lu R, Cohen P, Graham NA, Benayoun BA, Merry TL, Lee C
This study reported that circulating MOTS-c is induced by exercise and characterized age-related skeletal-muscle and physical-performance phenotypes in animal and human exercise contexts.
Pediatric diabetes · Du C, Zhang C, Wu W, Liang Y, Wang A, Wu S, Zhao Y, Hou L, Ning Q, Luo X
This observational study measured circulating MOTS-c in obese male children and adolescents and reported associations with insulin-resistance-related clinical variables.
Plain-English guides and study summaries from published literature.
Guides
4 min
From unrealistic expectations to poor support, several patterns appear again and again when people say MOTS-c made them feel worse.
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Guides
6 min
MOTS-c is often explored for mitochondrial signalling, but the shift from one energy pattern to another may not feel smooth at the start.
Read article
Guides
5 min
Some people report feeling more tired when they start MOTS-c. Here is the cleaner explanation for why that may happen and what the discussion usually centres on.
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Guides
7 min
Do you remember in middle school when we learned that mitochondria are the powerhouse of the cell? Well, as you age, your body produces less of a peptide that tells those mitochondria how to burn fat and use energy efficiently. And MOTS-C might be the signal your mitochondria have been missing.
Read article
Guides
6 min
How to mix, handle, and store peptides so you don’t ruin them If you’re new to peptides, the confusing part isn’t the vial of powder — it’s the fact that there are two different rulebooks: Before reconstitution (dry, lyophilized powder): you’re protecting it from moisture After reconstitution (liquid): you’re managing two clocks at once: Microbial safety Chemical stability (potency) Once you understand why those rules exist, you stop guessing and you stop accidentally degrading your product.
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Guides
4 min
Why most people use MOTS-C wrong — and how to run it the way it’s designed to work Quick take Most people run MOTS-C for fat loss and energy by itself, then wonder why the results don’t match what they expected. Using MOTS-C alone is like putting racing fuel in a car with a cracked engine block. The fuel isn’t the problem — the system can’t use it properly.
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